Among Massachusetts congressional districts – all represented by Democrats – this is the only one with a strong chance of going Republican.
The district includes the South Shore and Cape Cod, and gave Republican Sen. Scott Brown 60 percent of the vote in January's special election.
Every past effort to elect a Republican here since 1970 has failed, but this time around Republican Jeff Perry has a decent shot.
The race is considered a tossup, though Democrat Bill Keating – also running for the first time – has a slight edge.
In a strong Republican wave, Mr. Perry has a good shot of winning.
Though unlikely to be Republican victories, also keep an eye on the Fourth and Sixth Districts. That the Fourth, Barney Frank’s district, is in any danger is a sign of just how embattled Democrats are this year.
Massachusetts polls close at 8 p.m. Eastern.